Research Interests: neural stem cells, tumorigenesis, glioma biology
Dr. Persson’s research focuses on understanding how relevant oncogenic events can transform neural stem cells (NSCs) and oligodendrocyte progenitor cells (OPCs) to generate distinct types of childhood and adult gliomas.
In human gliomas, aggressive therapy leaves behind subpopulations of tumor cells displaying properties of NSCs or OPCs, suggesting a lineage-relationship between the cell of origin and therapy-resistant tumor cells. Recent publications confirm this relationship in genetically-engineered murine models (GEMM) of glioma. Other findings suggest that radiotherapy and changes in the tumor microenvironment can drive stemness and a proneural-mesenchymal transition in murine and human tumors.
Major goals of the Persson Laboratory include the following:
- Develop GEMM of glioma using relevant oncogenic events to identify the initial steps that transform NSCs and OPCs in a temporal and regional fashion.
- Identify drugable targets that drive stemness in glioma.
- Study whether interstitial fluid pressure (IFP), mechanosensing, and lipid rafts regulate tumor growth and relapse in glioma
1999: MS, Biochemistry, Gothenburg University, Sweden
2003: PhD, Neurobiology, Gothenburg University, Sweden
2004-2005: Research Associate, Department of Rehabilitation Medicine, Sahlgrenska Hospital, Sweden
2005-2008: Postdoctoral Fellow, Department of Neurology, UCSF
2008-2011: Assistant Adjunct Professor, Department of Neurology, UCSF
2012-Present: Assistant Professor in Residence, Department of Neurology and Neurological Surgery, UCSF
2018: American Brain Tumor Association Collaboration Award
2016: UCSF Program for Breakthrough Biomedical Research Award
2016: UC CRCC Early Career Developmental Award
2014: NIH/R21 Exploratory/Developmental Research Award
2013: Oligodendroglioma Award, National Brain Tumor Society
2012: American Cancer Society Individual Research Award
2011: Career Development Award, UCSF SPORE
2010: Hellman Family Foundation Early-Career Award
2010: American Brain Tumor Association Translational Research Award