UCSF adult and pediatric clinical trials

UCSF Brain Tumor Center Clinical Trials

Our clinical trials evaluate a broad range of innovative therapies for both adults and children with brain tumors. 

Identify Relevant Clinical Trials
Clinical Trial Phase
Intervention Model
Treatment Modality
Which of the following treatments has the patient already received?*
Genetic Features*
  • Recruiting Recruiting
  • Pediatrics Pediatrics
  • On Hold On Hold
Conditions
Glioma
Astrocytoma
Oligodendroglioma
Diffuse astrocytoma (grade II)
This clinical trial will evaluate the safety, tolerability, and anti-tumor activity of AG-120 or AG-881, when administered to patients with recurrent low-grade glioma before surgery.
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
Anaplastic astrocytoma (grade III)
Oligodendroglioma
Chemotherapy treatment of high grade gliomas (HGG), among other brain tumors, faces several challenges including the effective delivery of drugs to the tumor site. This clinical trial tests the combination of two different strategies for the delivery of a chemotherapy drug in patients with HGG.
Conditions
Glioma
Astrocytoma
Pleomorphic xanthoastrocytoma (grades II-III)
Brainstem Glioma
Diffuse astrocytoma (grade II)
Medulloblastoma
Atypical Teratoid / Rhaboid Tumor (AT/RT)
The purpose of this Phase I clinical trial is to evaluate the safety, dosage, and efficacy of entrectinib in treating children and young adults with solid tumors, primary CNS tumors, and neuroblastoma.
Conditions
Glioma
Astrocytoma
Pilocytic astrocytoma (grade I)
Pleomorphic xanthoastrocytoma (grades II-III)
Glioblastoma (grade IV)
This trial is testing the drug vemurafenib (also called PLX4032) in children with pediatric astrocytomas that have the BRAFV600E mutation. Vemurafenib works by blocking the activity of BRAF, a key protein in the RAS/RAF/MAPK pathway that is overactive in these tumors.
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
Anaplastic astrocytoma (grade III)
Diffuse astrocytoma (grade II)
Ependymoma
Oligodendroglioma
Meningioma
Pituitary Tumor
Craniopharyngioma
This is an observational study of patients with central nervous system (CNS) tumors who have been prescribed Gliadel Wafer by their physicians as part of usual care.
Conditions
Glioma
Astrocytoma
Pleomorphic xanthoastrocytoma (grades II-III)
Pilocytic astrocytoma (grade I)
Brainstem Glioma
Diffuse Midline Glioma
Atypical Teratoid / Rhaboid Tumor (AT/RT)
Subependymal giant cell astrocytoma (grade I)
Medulloblastoma
Choroid Plexus Tumors
The purpose of this Phase I clinical trial is to evaluate the safety and efficacy of the drug ramucirumab, in treating children with recurrent or refractory solid tumors, including CNS tumors.
Conditions
Glioma
Astrocytoma
Pleomorphic xanthoastrocytoma (grades II-III)
Pilocytic astrocytoma (grade I)
Brainstem Glioma
Diffuse Midline Glioma
Atypical Teratoid / Rhaboid Tumor (AT/RT)
Subependymal giant cell astrocytoma (grade I)
Choroid Plexus Tumors
Medulloblastoma
The purpose of this Phase I clinical trial is to study the side effects and best dose of entinostat in treating pediatric patients with recurrent or refractory solid tumors.

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