UCSF adult and pediatric clinical trials

UCSF Brain Tumor Center Clinical Trials

Our clinical trials evaluate a broad range of innovative therapies for both adults and children with brain tumors. 

Identify Relevant Clinical Trials
Clinical Trial Phase
Intervention Model
Treatment Modality
Which of the following treatments has the patient already received?*
Genetic Features*
  • Recruiting Recruiting
  • Pediatrics Pediatrics
  • On Hold On Hold
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
This clinical trial will investigate the use of oncolytic polio/rhinovirus recombinant (PVSRIPO) alone or in combination with chemotherapy in adult patients with recurrent grade IV glioma.
Recruiting
Conditions
Glioma
Astrocytoma
Oligodendroglioma
Diffuse astrocytoma (grade II)
This clinical trial will evaluate the safety, tolerability, and anti-tumor activity of AG-120 or AG-881, when administered to patients with recurrent low-grade glioma before surgery.
Recruiting
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
Anaplastic astrocytoma (grade III)
Oligodendroglioma
Chemotherapy treatment of high grade gliomas (HGG), among other brain tumors, faces several challenges including the effective delivery of drugs to the tumor site. This clinical trial tests the combination of two different strategies for the delivery of a chemotherapy drug in patients with HGG.
Recruiting
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
Anaplastic astrocytoma (grade III)
Pleomorphic xanthoastrocytoma (grades II-III)
Pilocytic astrocytoma (grade I)
Brainstem Glioma
Diffuse Midline Glioma
Atypical Teratoid / Rhaboid Tumor (AT/RT)
Ependymoma
Medulloblastoma
The purpose of this Phase I/II clinical trial is to evaluate the dosage, safety and efficacy of lenvatinib in combination with everolimus in treating pediatric patients with recurrent solid tumors, including central nervous system tumors.
Recruiting
Conditions
Glioma
Astrocytoma
Pleomorphic xanthoastrocytoma (grades II-III)
Brainstem Glioma
Diffuse astrocytoma (grade II)
Medulloblastoma
Atypical Teratoid / Rhaboid Tumor (AT/RT)
The purpose of this Phase I clinical trial is to evaluate the safety, dosage, and efficacy of entrectinib in treating children and young adults with solid tumors, primary CNS tumors, and neuroblastoma.
Recruiting
Conditions
Glioma
Astrocytoma
Anaplastic astrocytoma (grade III)
Glioblastoma (grade IV)
Pleomorphic xanthoastrocytoma (grades II-III)
Ependymoma
Medulloblastoma
Oligodendroglioma
Pilocytic astrocytoma (grade I)
Atypical Teratoid / Rhaboid Tumor (AT/RT)
Brainstem Glioma
Diffuse Midline Glioma
This phase II clinical trial tests the use of a precision medicine approach in treating pediatric patients with recurrent solid tumors, including central nervous system tumors. 
Recruiting
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
Anaplastic astrocytoma (grade III)
Diffuse astrocytoma (grade II)
Ependymoma
Oligodendroglioma
Meningioma
Pituitary Tumor
Craniopharyngioma
This is an observational study of patients with central nervous system (CNS) tumors who have been prescribed Gliadel Wafer by their physicians as part of usual care.
Recruiting
Conditions
Glioma
Astrocytoma
Glioblastoma (grade IV)
Anaplastic astrocytoma (grade III)
Diffuse astrocytoma (grade II)
Pleomorphic xanthoastrocytoma (grades II-III)
Pilocytic astrocytoma (grade I)
Ependymoma
Oligodendroglioma
This phase I clinical trial will evaluate the safety, efficacy and clinical activity of BGB-290 in combination with temozolomide, for treating adolescents and young adults with IDH1/2-mutant glioma (grades I-IV).

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