Research Interests: neurogenesis, stem cell biology
Dr. Alvarez-Buylla is internationally renowned for his work in developmental neuroscience and stem-cell neurobiology research. His principal research interests are in neurogenesis of the adult mammalian brain, neural stem cell regulation, the origin of brain tumors and brain repair.
His work contributed to major findings on the identification and characterization of neural stem cells in the adult brain. The Alvarez-Buylla laboratory has continued studying the way in which adult neural stem cells behave and function – the generation of young neurons, the migration of these neurons from their site of birth to their final destinations, and their function in the adult brain. Understanding the mechanisms that underlie neuronal proliferation, differentiation, migration, circuit integration may offer insights into new strategies for treating brain damage and diseases.
1983: Licenciado in Biomedical Research, Universidad Nacional Autonoma de Mexico
1988: PhD, Neurobiology, Rockefeller University
1988-1989: Postdoctoral Research, Rockefeller University
1989-1991: Assistant Professor, Rockefeller University
1991-1995: Assistant Professor-Head of Laboratory, Rockefeller University
1995-2000: Associate Professor-Head of Laboratory, Rockefeller University
2000-Present: Professor of Neurological Surgery, Heather and Melanie Muss Endowed Chair , UCSF
2017: 60th Annual Faculty Research Lectureship (FRL) in Basic Science
2016: Scientific Council of P.K. Anokhin Research Institute, Pentennial Medal, Russia
2014: Honorary Segerfalk Lecture Award/ Annual Neuroscience Day, Lund University, Sweden
2014: New York University, Honors Lecture, New York
2013: Catedra de Excelencia Banco de Santander, Pompeu Fabra University, Barcelona
2013: American Academy of Arts and Sciences, USA
2012: NICH; NIH Merit award
2011: Prince of Asturias Award for Technical and Scientific Research, Fundacíon Príncipe de Asturias, Spain. (Shared with Dr. Joseph Altman and Giacomo Rizzolatti)
2007: Catedra Ramón y Cajal, Sociedad Española de Neurología, Spain
2006: "Académico Correspondiente Extranjero”. Real Academia de Ciencias Exactas, Físicas y Naturales. Spain
2006: Catedra Santiago Grisolía, Spain. Lecture and Award, Spain
2003: NIH R01 HD032116-09. Origins of new neurons and glia in the postnatal brain
2002: Neuronal Plasticity Prize, Fondation IPSEN, France (Shared with Dr. R. McKay and Dr. S. Weiss
2000: Jacob Javits Award, 2000/NIH Grant RO1 NS28478
1992: Sinsheimer Award, USA
1990: First Award, NIH, The origin of new neurons in the adult avian brain
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A.
Nature. 2018; 555(7696):377-381.
Adult neurogenesis is sustained by symmetric self-renewal and differentiation
Obernier K, Cebrian-Silla A, Thomson M, Parraguez JI, Anderson R, Guinto C, Rodas Rodriguez J, Garcia-Verdugo JM, Alvarez-Buylla A.
Cell Stem Cell. 2018; 22(2):221-234.e8.
Generation of pure GABAergic neurons by transcription factor programming
Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, Wernig M.
Nature Methods. 2017; 14(6):621-628.