Research interests: stem cells, neural development, cell types and circuits in the brain
Dr. Cadwell completed her MD and PhD at Baylor College of Medicine in the lab of Dr. Andreas Tolias. As a student, she developed the Patch-seq technique for multimodal profiling of morphology, physiology and gene expression in single cells and applied Patch-seq and multipatching approaches to define the role of cell lineage in shaping cortical circuits. Dr. Cadwell completed clinical training in neuropathology here at UCSF and post-doctoral training in the lab of Dr. Tomasz Nowakowski studying how different cortical areas are specified during development and how early developmental events may contribute to neurological and neuropsychiatric disease. Her lab will focus on understanding how human cortical circuits form during development and how abnormal fate specification and circuit assembly contribute to neurological disorders such as focal epilepsies. The lab integrates molecular and physiological approaches to interrogate human cortical cell types and circuits, using both an induced pluripotent stem cell-derived cerebral organoid model as well as primary human tissues from patients undergoing neurosurgical resection.
2007: BS, Neuroscience and Biochemistry, Baylor University
2015: PhD, Neuroscience, Baylor College of Medicine
2016: MD, Baylor College of Medicine
2019: Residency, Anatomic Pathology, UCSF
2022-present: Assistant Professor, Neurological Surgery, UCSF