Research Interests: functional genomics, CNS cellular identity
The overarching goal of Dr. Oldham’s research is to understand the molecular basis of cellular identity in the human central nervous system (CNS) in health and disease, with a particular emphasis on glioma. Toward this end, the Oldham lab develops and applies standardized computational and experimental strategies for deconstructing complex biological systems. These efforts seek to precisely quantify the cellular composition of human CNS samples while simultaneously distilling the core molecular features of cellular identity. By comparing these features between non-pathological and pathological human tissue samples, the Oldham lab seeks to expand the druggable search space for glioma and other human brain tumors.
1996: BS, Duke University
2009: PhD, University of California Los Angeles
2010: Postdoctoral Scholar, University of California Los Angeles
2010-2015: UCSF Sandler Faculty Fellow, Department of Neurology and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
2015-Present: Assistant Professor, Department of Neurological Surgery, UCSF
2016: Weill Institute for Neurosciences Scholar Award, UCSF
2015: Program for Breakthrough Biomedical Research New Frontiers Award, UCSF
2012: Young Investigator, Sage Commons Congress, San Francisco, CA
2009: Sandler Faculty Fellow, UCSF
2008: Eva Kavan Prize for Excellence in Research on the Brain, Brain Research Institute, UCLA
Functional organization of the transcriptome in human brain
Oldham MC, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S, Geschwind DH.
Nat Neurosci. 2008 Nov;11(11):1271-82. doi: 10.1038/nn.2207. Epub 2008 Oct 12.
Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex
Lui JH, Nowakowski TJ, Pollen AA, Javaherian A, Kriegstein AR, Oldham MC.
Nature. 2014 Nov 13;515(7526):264-8.