Michael Oldham, PhD
Research Interests: Human neurobiology, gliomas, tumor microenvironment, tumor vasculature, bioinformatics, multiscale and multiomic analysis
The overarching goal of Dr. Oldham’s research is to understand the cellular and molecular composition of human brain samples in health and disease, with an emphasis on adult malignant gliomas. Toward this end, the Oldham lab uses robotic automation to standardize production of large omics datasets from human brain samples, which are analyzed with custom computational pipelines to relate oncogenic mutations to patterns of molecular activity in malignant cells and the tumor microenvironment. These efforts seek to precisely quantify the cellular composition of human CNS samples while simultaneously distilling the core molecular features of cellular identity. By comparing these features between normal and pathological human brain samples, the Oldham lab seeks to expand the druggable search space for malignant gliomas and other human brain tumors.
1996: BS, Duke University
2009: PhD, University of California Los Angeles
2010: Postdoctoral Scholar, University of California Los Angeles
2010-2015: UCSF Sandler Faculty Fellow, Department of Neurology and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
2015-2020: Assistant Professor, Department of Neurological Surgery, UCSF
2020-Pressent: Associate Professor, Department of Neurological Surgery, UCSF
2017-Present: NIH Principal Investigator, UCSF
2016: Weill Institute for Neurosciences Scholar Award, UCSF
2015: Program for Breakthrough Biomedical Research New Frontiers Award, UCSF
2012: Young Investigator, Sage Commons Congress, San Francisco, CA
2009: Sandler Faculty Fellow, UCSF
2008: Eva Kavan Prize for Excellence in Research on the Brain, Brain Research Institute, UCLA
Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections
Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC.
bioRxiv [Preprint]. 2023 Aug 21. doi: 110.1101/2023.06.21.545365.
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes
Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham MC.
Nat Neurosci. 2018 Sep;21(9):1171-1184.
Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex
Lui JH, Nowakowski TJ, Pollen AA, Javaherian A, Kriegstein AR, Oldham MC.
Nature. 2014 Nov 13;515(7526):264-8.