Understanding the basic mechanisms underlying normal developmental processes (like cell division, differentiation, and migration) in the brain can provide insight into how those same pathways are dysregulated or co-opted during tumorigenesis.
Some active areas of developmental biology research at UCSF include the following:
- Mechanisms of adult neurogenesis and neuronal replacement
- Signaling pathways and transcription factors regulating gliogenesis
- Mechanisms underlying cell fate decision in oligodendrocyte precursor cells
- Long non-coding RNA in neural development and glioma growth
- Mechanisms of DNA repair in neural stem cells