Genomics is the study of the genome, or the whole set of genes present in a cell or organism. Analysis of tumor DNA and RNA may aid our understanding of brain tumor subtypes and how specific mutations influence tumor growth, progression, recurrence, and treatment response.
Taking advantage of recent innovations in next generation sequencing, RNA sequencing, and various bioinformatic approaches, some areas of active genomics research at UCSF include the following:
- Investigation of tumor heterogeneity and evolution
- Analysis of gene expression in the human brain to isolate transcriptional signatures of distinct cell types
- Identification of biomarkers through analysis of genetic, epigenetic, and transcriptional features of glioma
- Development of therapeutic targets for glioma treatment, using computational approaches to find driver genes and pathways mediating cancer progression
- Use of CRISPR to identify genes driving glioblastoma tumor development