UCSF Brain Tumor Center Clinical Trials

Primary Objectives:

The goal of this registry study is to collect more information to help identify clinical, biological, and imaging factors that can predict outcomes for ATRT.

This is an open-label, comprehensive, iterative investigation of evaluating the use of induction chemotherapy, high-dose chemotherapy, and focal radiation therapy in children with newly diagnosed Embryonal Tumor With Multilayered Rosettes (ETMR).

This is a platform trial for children, adolescents, and young adults with recurrent or progressive ATRT. 

The primary objective of the trial is to determine if there is a difference in rate of rebound and/or clinical progression necessitating the reinstitution of treatment at 4 months after stopping or weaning therapy with dabrafenib and trametinib in participants with newly diagnosed or recurrent/pr

There are very few treatment options for children and young adults whose posterior fossa Group A (PFA) ependymoma has come back or continued to grow after surgery and radiation.

Pediatric low-grade gliomas are the most common brain tumors in children and adolescents, often presenting significant long-term treatment challenges. Surgical resection remains the cornerstone of treatment, but complete removal is not always feasible.

This is a randomized phase 2 clinical trial evaluating the safety and efficacy of adding a type of immunotherapy called a dendritic cell vaccine to the standard of care for adult patients newly diagnosed with glioblastoma.